Home

Let’s end the era
of untreatable
disease.

Undruggable
no more.

Researchers have discovered hundreds of drug targets to treat disease—and find more every day. But until recently, 90% of these targets have been considered ​“undruggable,” and therefore untreatable. Using our revolution­ary high-throughput platform, we can now discover drugs at a volume, speed, and efficiency thousands of times greater than has ever been possible.

We are designing life-changing medicines at genomic scale.

01 Power

Covalent molecules serve as a universal key to unlocking undruggable targets for both non-covalent and covalent drug development. Many of the most effective therapeutics in history, including penicillin, AZT, and many lifechanging oncology drugs were developed through this approach.

Watch video
02 Scale

The Totus Platform discovers drugs with unprecedented volume, speed, and efficiency, allowing us to create a comprehensive catalog of drugs across the entire human genome.

See our platform
03 Impact

We are developing drugs against poorly treated, advanced forms of cancer, starting with a breakthrough medicine for the most mutated oncogene. We have also built out a robust pipeline of oncology programs.

See our pipeline
Two Totus team members in the lab having a conversation while working.

We have the power to treat cancer, heart disease, neurodegen­er­a­tion, and beyond—within this decade.